Common antidepressants interact with opioid med to lessen pain relief

(University Hospitals Cleveland Medical Center) Common antidepressants interact with the opioid pain medication tramadol to make it less effective for pain relief, according to a study published in the journal Pharmacotherapy. These findings have important implications for the opioid epidemic, suggesting that some patients suspected of drug-seeking may in fact be under-medicated and just are seeking more effective pain relief. They also could help explain why some people exceed the prescribed do...